A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
← catalyst calendarNCT07636811 · readout in 1,368 d
Sponsored by Alnylam Pharmaceuticals (industry) · ALNY — their whole pipeline →.
Phase
Phase 2
Status
Recruiting
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
58estimated
Sites
2
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-08-31 | estimated | When the study began enrolling |
| Primary completion | 2030-05-18 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2031-07-23 | estimated | The whole study's end, after follow-up |
| First posted | 2026-06-09 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-12 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Down Syndrome-Associated Alzheimer's Disease (DS-AD)
Interventions
- Drug: Mivelsiran — also filed as ALN-APP
- Drug: Placebo
Primary outcome
what the primary-completion date above is the date OFDouble-Blind Period: Change from baseline in brain amyloid burden measured in centiloids (CLs)
measured Up to 24 months
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