Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
← catalyst calendarNCT07621718 · readout in 864 d
Sponsored by Revolution Medicines, Inc. (industry) · RVMD — their whole pipeline →.
Phase
Phase 3
Status
Recruiting
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
670estimated
Sites
5
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-05-22 | actual | When the study began enrolling |
| Primary completion | 2028-12-30 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2030-04-22 | estimated | The whole study's end, after follow-up |
| First posted | 2026-06-02 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-03 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Pancreatic Cancer
- Pancreatic Cancer Metastatic
- PDAC
- PDAC - Pancreatic Ductal Adenocarcinoma
- Pancreatic Ductal Adenocarcinoma (PDAC)
- Pancreatic Adenocarcinoma Metastatic
- Pancreatic Adenocarcinoma
- Pancreatic Adenosquamous Carcinoma
Interventions
- Drug: Zoldonrasib
- Drug: Placebo
- Drug: Oxaliplatin
- Drug: Leucovorin (Calcium Folinate)
- Drug: 5-Fluorouracil
- Drug: Irinotecan
- Drug: Gemcitabine (GEM)
- Drug: Nab-paclitaxel
Primary outcomes
what the primary-completion date above is the date OFProgression free survival (PFS)
measured Up to approximately 4 years
Overall survival (OS)
measured Up to approximately 4 years
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