A Study to Access Activity and Safety With SAR445399 Compared With Placebo in Participants Aged 18 to 80 Years of Age With Non-Cystic Fibrosis Bronchiectasis
← catalyst calendarNCT07547436 · readout in 436 d
Sponsored by Sanofi (industry) · SNY — their whole pipeline →.
Phase
Phase 2
Status
Suspended
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
70estimated
Sites
4
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The pause is for strategic business reasons to facilitate internal portfolio review. The pause is not due to any concerns with patient safety, with program benefit/risk, or with trial integrity.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-06-08 | actual | When the study began enrolling |
| Primary completion | 2027-10-29 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2029-05-11 | estimated | The whole study's end, after follow-up |
| First posted | 2026-04-23 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-29 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Non-cystic Fibrosis Bronchiectasis
Interventions
- Biological: SAR445399
- Biological: Placebo
Primary outcome
what the primary-completion date above is the date OFChange from baseline to Week 24 in mucus plug score (MPS) derived from chest high-resolution computerized tomography (HRCT)
measured from baseline up to Week 24
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