A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
← catalyst calendarNCT07492680 · readout in 726 d
Sponsored by Bristol-Myers Squibb (industry) · BMY — their whole pipeline →.
Phase
Phase 2
Status
Recruiting
Study type
Interventional
Design
Na · None · Treatment
Enrollment
260estimated
Sites
57
Countries
Belgium, Canada, China +10
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-07-27 | actual | When the study began enrolling |
| Primary completion | 2028-08-15 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2032-05-20 | estimated | The whole study's end, after follow-up |
| First posted | 2026-03-25 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-30 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Solid Tumors
Interventions
- Drug: BMS-986504 — also filed as MRTX1719, Navlimetostat
- Drug: Daraxonrasib — also filed as RMC 6236
- Drug: Nivolumab + Relatlimab FDC
- Drug: Temozolomide
- Drug: Pumitamig — also filed as BNT327
- Drug: Pemetrexed
- Drug: Carboplatin
- Drug: Nab-paclitaxel
- Drug: Gemcitabine
- Drug: Paclitaxel
Primary outcomes
what the primary-completion date above is the date OFPart 1: Number of participants who achieve Objective Response (OR)
measured Up to approximately 2 years
Part 2: Number of participants with adverse events meeting protocol defined dose limiting toxicities (DLTs) criteria
measured Up to approximately 2 years
Part 2: Number of participants with adverse events (AE)
measured Up to approximately 2 years
Part 2: Number of participants with Serious AEs (SAEs)
measured Up to approximately 2 years
Part 2: Number of participants with treatment related AEs
measured Up to approximately 2 years
Part 2: Number of participants with treatment related SAEs
measured Up to approximately 2 years
Part 2: Number of participants with AEs leading to study treatment discontinuation
measured Up to approximately 2 years
Part 2: Number of participants with AEs leading to death
measured Up to approximately 2 years
Part 2: Number of participants with laboratory abnormalities
measured Up to approximately 2 years
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