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A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

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NCT07492680 · readout in 726 d

Sponsored by Bristol-Myers Squibb (industry) · BMY — their whole pipeline →.

Phase
Phase 2
Status
Recruiting
Study type
Interventional
Design
Na · None · Treatment
Enrollment
260estimated
Sites
57
Countries
Belgium, Canada, China +10

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2026-07-27actualWhen the study began enrolling
Primary completion2028-08-15estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completion2032-05-20estimatedThe whole study's end, after follow-up
First posted2026-03-25actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-07-30actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Solid Tumors

Interventions

  • Drug: BMS-986504 — also filed as MRTX1719, Navlimetostat
  • Drug: Daraxonrasib — also filed as RMC 6236
  • Drug: Nivolumab + Relatlimab FDC
  • Drug: Temozolomide
  • Drug: Pumitamig — also filed as BNT327
  • Drug: Pemetrexed
  • Drug: Carboplatin
  • Drug: Nab-paclitaxel
  • Drug: Gemcitabine
  • Drug: Paclitaxel

Primary outcomes

what the primary-completion date above is the date OF
Part 1: Number of participants who achieve Objective Response (OR)
measured Up to approximately 2 years
Part 2: Number of participants with adverse events meeting protocol defined dose limiting toxicities (DLTs) criteria
measured Up to approximately 2 years
Part 2: Number of participants with adverse events (AE)
measured Up to approximately 2 years
Part 2: Number of participants with Serious AEs (SAEs)
measured Up to approximately 2 years
Part 2: Number of participants with treatment related AEs
measured Up to approximately 2 years
Part 2: Number of participants with treatment related SAEs
measured Up to approximately 2 years
Part 2: Number of participants with AEs leading to study treatment discontinuation
measured Up to approximately 2 years
Part 2: Number of participants with AEs leading to death
measured Up to approximately 2 years
Part 2: Number of participants with laboratory abnormalities
measured Up to approximately 2 years

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