A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
← catalyst calendarNCT07481630 · readout in 725 d
Sponsored by Novo Nordisk A/S (industry) · NVO — their whole pipeline →.
Phase
Phase 3
Status
Recruiting
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
400estimated
Sites
82
Countries
Australia, Bulgaria, Canada +7
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-04-13 | actual | When the study began enrolling |
| Primary completion | 2028-08-14 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-08-14 | estimated | The whole study's end, after follow-up |
| First posted | 2026-03-19 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-09 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Obesity
- Knee Osteoarthritis (OA)
Interventions
- Drug: NNC0487-0111
- Drug: Placebo (matched to NNC0487-0111 )
Primary outcomes
what the primary-completion date above is the date OFRelative change in body weight
measured From baseline (week 0) to (week 80)
Change in WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) pain score
measured From baseline (week 0) to (week 80)
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