A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.
← catalyst calendarNCT07470853 · readout ≤ 558 d
Sponsored by Whitehawk Therapeutics, Inc. (industry) · WHWK — their whole pipeline →. With Catalyst Pharmaceutical Research.
Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
265estimated
Sites
12
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-03-15 | actual | When the study began enrolling |
| Primary completion | Feb 2028 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | Feb 2028 | estimated | The whole study's end, after follow-up |
| First posted | 2026-03-13 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-18 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- PROC
- Platinum Resistant Ovarian Cancer
- Endometrial Cancer
Interventions
- Drug: HWK-016, MUCIN-16-targeted ADC — also filed as HWK-016
- Drug: Bevacizumab
Primary outcomes
what the primary-completion date above is the date OFDetermine Maximum Tolerated Dose (MTD)
measured From Cycle 1, Day 1 Until Cycle 1, Day 21 (21-day cycles)
Determine Maximum Administered Dose (MAD)
measured From Cycle 1, Day 1 to Cycle 1, Day 21 (21-day cycles) until the MTD is reached.
Determine Recommended Dose For Expansion (RDE)
measured From Cycle 1, Day 1 to Cycle 1, Day 21 (21-day cycle) until MTD is identified.
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