Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors
← catalyst calendarNCT07349537 · readout ≤ 620 d
Sponsored by Revolution Medicines, Inc. (industry) · RVMD — their whole pipeline →.
Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
574estimated
Sites
9
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2026-01-08 | actual | When the study began enrolling |
| Primary completion | Apr 2028 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | Oct 2028 | estimated | The whole study's end, after follow-up |
| First posted | 2026-01-16 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-10 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Non-small Cell Lung Cancer (NSCLC)
- Colorectal Cancer (CRC)
- Pancreatic Adenocarcinoma
- Pancreatic Ductal Adenocarcinoma (PDAC)
- PDAC
- CRC
- NSCLC
- Pancreatic Cancer
- Lung Cancer (NSCLC)
- Advanced Solid Tumors
Interventions
- Drug: RMC-5127
- Drug: daraxonrasib
- Drug: cetuximab
Primary outcomes
what the primary-completion date above is the date OFNumber of patients with adverse events (AEs)
measured Up to approximately 3 years
Changes in vital signs
measured Up to approximately 3 years
Changes in electrocardiogram (ECG) test values
measured Up to approximately 3 years
Changes in clinical laboratory test values
measured Up to approximately 3 years
Dose Limiting Toxicities
measured Up to 28 days
Permalink · RVMD's whole pipeline · Catalyst calendar · Every registered study · What changed