Pharmacokinetics of Olverembatinib in Participants With Hepatic Impairment
← catalyst calendarSponsored by Ascentage Pharma Group Inc. (industry) · AAPG — their whole pipeline →. With Guangzhou Healthquest Pharma Co., Ltd.
Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
48estimated
Sites
1
Country
China
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-11-11 | actual | When the study began enrolling |
| Primary completion | 2026-06-30 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-10-31 | estimated | The whole study's end, after follow-up |
| First posted | 2025-12-15 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-12-23 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Pharmacokinetic
- Olverembatinib
Intervention
- Drug: Olverembatinib 20mg
Primary outcomes
what the primary-completion date above is the date OFMaximum observed plasma concentration C(max)
measured Day 1 to Day 9
Time to C(max) [ t(max) ]
measured Day 1 to Day 9
Apparent terminal elimination half-life (t½)
measured Day 1 to Day 9
Area under the concentration-time curve from time zero to last time of quantifiable concentration [AUC(last)]
measured Day 1 to Day 9
Area under the concentration-time curve from time zero to 192h AUC(0-192h)
measured Day 1 to Day 9
Apparent Clearance (CL/F)
measured Day 1 to Day 9
Apparent Volume of distribution (Vz/F)
measured Day 1 to Day 9
Unbound Fraction (fu)
measured Day 1 to Day 9
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