A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With and Without Reduced Liver Function
← catalyst calendarNCT07269301 · readout in 188 d
Sponsored by Pfizer (industry) · PFE — their whole pipeline →.
Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Basic science
Enrollment
26estimated
Sites
3
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-12-22 | actual | When the study began enrolling |
| Primary completion | 2027-02-23 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-02-23 | estimated | The whole study's end, after follow-up |
| First posted | 2025-12-08 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-23 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Hepatic Impairment
- Healthy
Intervention
- Drug: PF-07328948
Primary outcomes
what the primary-completion date above is the date OFFraction of Unbound Drug in Plasma (Fu) of PF-07328948
measured At 0 (prior to dose), 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, 72, 96, 120, and 168 hours post dose on Day 1
Unbound AUCinf (AUCinf,u) of PF-07328948
measured At 0 (prior to dose), 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, 72, 96, 120, and 168 hours post dose on Day 1
Unbound Cmax (Cmax,u) of PF-07328948
measured At 0 (prior to dose), 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 24, 36, 48, 72, 96, 120, and 168 hours post dose on Day 1
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