A Study to Learn If the Study Medicine Called PF-08049820 Changes How the Body Processes the Other Study Medicines Called Oral Contraceptives, Midazolam, and Dabigatran in Healthy Adult Female Participants
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Phase
Phase 1
Status
Active, not recruiting
Study type
Interventional
Design
Non randomized · None · Basic science
Enrollment
16actual
Sites
1
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-10-03 | actual | When the study began enrolling |
| Primary completion | 2025-12-15 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-12-15 | estimated | The whole study's end, after follow-up |
| First posted | 2025-09-24 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-12-09 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Atopic Dermatitis
Interventions
- Drug: PF-08049820
- Drug: Midazolam
- Drug: Dabigatran Etexilate
- Drug: Portia (EE and LN) or equivalent oral tablet
Primary outcomes
what the primary-completion date above is the date OFPharmacokinetics (PK): Area Under the curve (AUC) of Midazolam
measured From pre-dose up to 24 hours post dose in Periods 1 and 4
PK: Plasma Maximum Concentration (Cmax) of Midazolam
measured From pre-dose up to 24 hours post dose in Periods 1 and 4
PK: Area Under the curve (AUC) of dabigatran
measured From pre-dose up to 48 hours post dose in Periods 2 and 5
PK: Cmax of dabigatran
measured From pre-dose up to 48 hours post dose in Periods 2 and 5
PK: AUC of Ethinyl estradiol and levonorgestrel
measured From pre-dose up to 96 hours post dose in Periods 3 and 6
PK: Cmax of Ethinyl estradiol and levonorgestrel
measured From pre-dose up to 96 hours post dose in Periods 3 and 6
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