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A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

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NCT07059845 · readout ≤ 896 d

Sponsored by AbbVie (industry) · ABBV — their whole pipeline →.

Phase
Phase 2
Status
Recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
400estimated
Sites
82
Countries
Australia, Belgium, Czechia +5

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2025-11-13actualWhen the study began enrolling
Primary completionJan 2029estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completionJan 2029estimatedThe whole study's end, after follow-up
First posted2025-07-11actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-08-04actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Ovarian Cancer

Interventions

  • Drug: Mirvetuximab Soravtansine
  • Drug: Bevacizumab
  • Drug: Carboplatin

Primary outcomes

what the primary-completion date above is the date OF
Substudy 1, 2, and 3: Number of Participants with Treatment-Emergent Adverse Events (TEAEs) (any grade, Grade >= 3)
measured Up to Approximately 40 Months
Substudy 1, 2, and 3: Number of Participants with TEAEs Leading to Discontinuation
measured Up to Approximately 40 Months
Substudy 1, 2, and 3: Number of Participants with Ocular Adverse Events (AEs) (any grade, Grade >= 2)
measured Up to Approximately 40 Months
Substudy 1, 2, and 3: Overall Response (OR) as Assessed by the Investigator per RECIST v1.1
measured Up to Approximately 40 Months
Substudy 1: Progression free survival (PFS) as Assessed by the Investigator per RECIST v1.1
measured Up to Approximately 40 Months

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