To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants
← catalyst calendarSponsored by Eli Lilly and Company (industry) · LLY — their whole pipeline →.
Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Na · None · Basic science
Enrollment
30actual
Sites
1
Country
Singapore
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-02-03 | actual | When the study began enrolling |
| Primary completion | 2025-04-15 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-04-15 | actual | The whole study's end, after follow-up |
| First posted | 2025-02-05 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-06-05 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Healthy
Interventions
- Drug: Retatrutide — also filed as LY3437943
- Drug: Metoprolol
Primary outcomes
what the primary-completion date above is the date OFPharmacokinetics (PK): Area Under Concentration From Time Zero to Infinity (AUC[0-∞]) of Metoprolol
measured Day 1 to Day 3
Pharmacokinetics (PK): AUC (0-∞) of Metoprolol with Retatrutide
measured Day 9 to Day 11
PK: Maximum Concentration (Cmax) of Metoprolol
measured Day 1 to Day 3
PK: Cmax of Metoprolol with Retatrutide
measured Day 9 to Day 11
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