A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors
← catalyst calendarNCT06803680 · readout in 619 d
Sponsored by BeOne Medicines (industry) · ONC — their whole pipeline →.
Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
90estimated
Sites
12
Countries
Australia, China, United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-03-18 | actual | When the study began enrolling |
| Primary completion | 2028-04-29 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-04-29 | estimated | The whole study's end, after follow-up |
| First posted | 2025-01-31 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-10 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Advanced Solid Tumor
- Metastatic Solid Tumor
Interventions
- Drug: BGB-B455
- Drug: Chemotherapy
Primary outcomes
what the primary-completion date above is the date OFPhase 1a: Number of participants with adverse events (AEs) and serious adverse events (SAEs)
measured From the first dose of study drug(s) to 30 days after the last dose or initiation of a new anticancer therapy, whichever occurs first; up to approximately 7 months
Phase 1a: Maximum Tolerated Dose (MTD) or Maximum Administered Dose (MAD) of BGB-B455
measured Approximately 1 month
Phase 1a: RDFE of BGB-B455
measured Approximately 1 month
Phase 1b: Overall Response Rate (ORR)
measured Approximately 18 months
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