A Drug-Drug Interaction Study of S-217622 With Combined Oral Contraceptives in Healthy Adult Female Participants
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Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Na · None · Treatment
Enrollment
24actual
Sites
1
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-12-30 | actual | When the study began enrolling |
| Primary completion | 2025-04-03 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-04-03 | actual | The whole study's end, after follow-up |
| First posted | 2025-01-15 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-05-04 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Healthy Adult Female Participants
Intervention
- Drug: Ensitrelvir — also filed as S-217622
Primary outcomes
what the primary-completion date above is the date OFMaximum Plasma Concentration (Cmax) of Ethinyl Estradiol (EE)
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
Cmax of Drospirenone (DRSP)
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
Time to Reach Cmax (Tmax) of EE
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
Tmax of DRSP
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
Area Under the Plasma Concentration-time Curve Over the Dosing Interval (AUC0-τ) of EE
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
AUC0-τ of DRSP
measured Predose and up to 24 hours postdose on Days 19, 20, and 24
Publications
- PMID 41915378 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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