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Study to Evaluate the Pharmacokinetics and Pharmacodynamics of AZD4604 Given Via the Turbuhaler® Device in Adults With Mild Asthma.

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NCT06732882

Sponsored by AstraZeneca (industry) · AZN — their whole pipeline →.

Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
28actual
Sites
10
Countries
Germany, United Kingdom

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2025-02-27actualWhen the study began enrolling
Primary completion2025-05-29actualThe date the last participant is measured for the primary outcome — the readout window
Study completion2025-05-29actualThe whole study's end, after follow-up
First posted2024-12-13actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2025-06-05actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Asthma

Interventions

  • Drug: AZD4604
  • Other: Placebo
  • Device: Genuair
  • Device: Turbuhaler

Primary outcomes

what the primary-completion date above is the date OF
Maximum observed drug concentration (Cmax) of AZD4604
measured Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Time to reach maximum observed concentration (tmax) of AZD4604
measured Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Area under concentration-time curve in the dosing interval (AUCtau) of AZD4604
measured Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Apparent total body clearance (CL/F) of AZD4604
measured Day 10 (Pre-dose and Post-dose)
Apparent volume of distribution based on the terminal phase (VZ/F) of AZD4604
measured Day 10 (Pre-dose and Post-dose)
Dose normalised AUCtau (AUCtau/D) of AZD4604
measured Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)
Dose normalised Cmax (Cmax/D) of AZD4604
measured Day 9 (Pre-dose) and Day 10 (Pre-dose and Post-dose)

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