Estimated Vaccine Effectiveness and Durability of Pfizer/BioNTech 2024-2025 COVID-19 Vaccine
← catalyst calendarSponsored by Pfizer (industry) · PFE — their whole pipeline →. With CVS Caremark.
Phase
—
Status
Terminated
Study type
Observational
Enrollment
1actual
Sites
1
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
This secondary data analysis of symptomatic CVS MinuteClinics patients testing for SARS-CoV-2 was terminated due to incomplete data on KP.2 vaccination status (exposure). Termination was not based on any safety concerns or regulatory requirements.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-11-25 | actual | When the study began enrolling |
| Primary completion | 2025-06-06 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-06-06 | actual | The whole study's end, after follow-up |
| First posted | 2024-11-25 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-11-06 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- COVID-19
Interventions
- Biological: Pfizer-BioNTech BNT162b2 COVID-19 Vaccinated — also filed as Exposed
- Biological: Not vaccinated with 2024-2025 formulated COVID-19 vaccine — also filed as Unexposed
Primary outcomes
what the primary-completion date above is the date OFNumber of Pfizer/BioNTech 2024-2025 formulation vaccinated patients who test positive for SARS-CoV-2 ≥14 days after receipt of vaccine
measured September 2024 - April 2025
Number of COVID-19 2024-2025 formulation unvaccinated patients who test positive for SARS-CoV-2
measured September 2024 - April 2025
Number of Pfizer/BioNTech 2024-2025 formulation vaccinated patients who test negative for SARS-CoV-2 ≥14 days after receipt of vaccine
measured September 2024 - April 2025
Number of COVID-19 2024-2025 formulation unvaccinated patients who test negative for SARS-CoV-2
measured September 2024 - April 2025
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