Clinical Study to Evaluate the Safety and the Efficacy of EscharEx Drug Product (EX-03 Formulation) and Its Placebo Compared to Collagenase, Non-surgical Standard of Care, in Patients With Venous Leg Ulcers
← catalyst calendarNCT06690177 · readout in 497 d
Sponsored by MediWound Ltd (industry) · MDWD — their whole pipeline →.
Phase
Phase 2
Status
Not yet recruiting
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
45estimated
Sites
2
Countries
Poland, United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2025-04-30 | estimated | When the study began enrolling |
| Primary completion | 2027-12-30 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-09-30 | estimated | The whole study's end, after follow-up |
| First posted | 2024-11-15 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2024-11-15 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Venus Leg Ulcers
Interventions
- Drug: EscharEx (EX-03)
- Drug: Placebo (Gel vehicle)
Primary outcomes
what the primary-completion date above is the date OFIncidence (number of patients) of target wound related AEs throughout the trial
measured Throughout the study (week 2- week 15)
Number of patients with Clinically significant changes in vital signs during the Daily Visits Period,
measured Weeks 2-3 (14 days)
Number of patients with Clinically significant changes in clinical laboratory parameters
measured Weeks 2-3 (14 days)
Time to complete wound closure
measured Weeks 2-15
Incidence of complete wound closure
measured 2-15 weeks
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