An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug Interactions
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Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Non randomized · None · Other
Enrollment
59actual
Sites
1
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-09-25 | actual | When the study began enrolling |
| Primary completion | 2025-02-17 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-02-17 | actual | The whole study's end, after follow-up |
| First posted | 2024-11-04 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-04-27 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Dyslipidaemia
Interventions
- Drug: AZD0780
- Drug: Itraconazole
- Drug: Carbamazepine
- Drug: Midazolam
- Drug: Ethinyl estradiol/levonorgestrel
Primary outcomes
what the primary-completion date above is the date OFAUCinf (Area under concentration-time curve from time 0 to infinity)
measured Period 1 (Day 1 to 11 Cohort 1 and Cohort 2) and Period 3 (Day 14-24 Part 1 and Day 27-37 Part 2)
AUClast (Area under concentration curve from time 0 to the last quantifiable concentration)
measured Period 1 (Day 1 to 11 Cohort 1 and Cohort 2) and Period 3 (Day 14-24 Part 1 and Day 27-37 Part 2)
Cmax (Maximum observed drug concentration)
measured Period 1 (Day 1 to 11 Cohort 1 and Cohort 2) and Period 3 (Day 14-24 Part 1 and Day 27-37 Part 2)
AUCinf
measured Period 1 (Day 1 to 2 Part 3 and Day 1 to 7 Part 4) and Period 3 (Day 11-12 Part 3 and Day 16 to 22 Part 4)
AUClast
measured Period 1 (Day 1 to 2 Part 3 and Day 1 to 7 Part 4) and Period 3 (Day 11-12 Part 3 and Day 16 to 22 Part 4)
Cmax
measured Period 1 (Day 1 to 2 Part 3 and Day 1 to 7 Part 4) and Period 3 (Day 11-12 Part 3 and Day 16 to 22 Part 4)
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