A Study of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus (T2DM)
← catalyst calendarSponsored by Amgen (industry) · AMGN — their whole pipeline →.
Phase
Phase 2
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
409actual
Sites
96
Countries
Austria, Greece, Hong Kong +11
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-11-07 | actual | When the study began enrolling |
| Primary completion | 2025-10-06 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-11-10 | estimated | The whole study's end, after follow-up |
| First posted | 2024-10-28 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-11-25 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Type 2 Diabetes Mellitus (T2DM)
Interventions
- Drug: Maridebart Cafraglutide — also filed as AMG 133
- Drug: Placebo
Primary outcome
what the primary-completion date above is the date OFChange From Baseline to Week 24 in Hemoglobin A1c (HbA1c)
measured Baseline to Week 24
Permalink · AMGN's whole pipeline · Catalyst calendar · Every registered study · What changed