AZD3427 Effects on Renal Perfusion in Heart Failure Patients With Reduced Ejection Fraction and Renal Impairment
← catalyst calendarSponsored by AstraZeneca (industry) · AZN — their whole pipeline →. With CTC Clinical Trial Consultants AB, Karolinska Institutet.
Phase
Phase 1
Status
Terminated
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
10actual
Sites
1
Country
Sweden
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The Sponsor encountered difficulties in recruiting patients for clinical trial D8330C00004 and decided to end the study earlier for business reasons not affecting the benefit-risk balance.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-10-15 | actual | When the study began enrolling |
| Primary completion | 2025-08-21 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-08-21 | actual | The whole study's end, after follow-up |
| First posted | 2024-09-25 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-09-24 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF)
- Renal Impairment
Interventions
- Biological: AZD3427
- Other: AZD3427 Placebo
- Drug: Dopamine
- Other: Radiolabelled ligand
- Other: Saline
Primary outcome
what the primary-completion date above is the date OFThe volumetric fraction (%) of the renal cortex with increased perfusion from baseline to Day 8, compared to placebo.
measured Baseline to Day 8
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