A Long-term Observational Study Evaluating Eteplirsen, Golodirsen, or Casimersen in Routine Clinical Practice

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NCT06606340 · readout in 2,691 d

Sponsored by Sarepta Therapeutics, Inc. (industry) · SRPT — their whole pipeline →.

Phase

—

Status

Enrolling by invitation

Study type

Observational

Enrollment

300estimated

Sites

Country

United States

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis

Date

Filed

Basis

What it is

Start

2019-01-07

actual

When the study began enrolling

Primary completion

2033-12-31

estimated

The date the last participant is measured for the primary outcome — the readout window

Study completion

2033-12-31

estimated

The whole study's end, after follow-up

First posted

2024-09-23

actual

When this record first appeared on the registry

Results posted

—

When the sponsor posted results to the registry

Record updated

2025-09-10

actual

The sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

Duchenne Muscular Dystrophy

Interventions

Drug: Eteplirsen — also filed as AVI-4658, EXONDYS 51, EXONDYS
Drug: Golodirsen — also filed as SRP-4053, VYONDYS 53
Drug: Casimersen — also filed as SRP-4045, AMONDYS 45

Primary outcomes

what the primary-completion date above is the date OF

Loss of Ambulation (LOA)

measured Up to 5 years

Time to Rise From the Floor (Supine to Stand)

measured Up to 5 years

Time to Walk/Run 10 Meters

measured Up to 5 years

Performance of Upper Limb Module for DMD 2.0 (PUL 2.0) Entry Item A

measured Up to 5 years

Pulmonary Function, as Measured by Forced Vital Capacity (FVC) (% Predicted)

measured Up to 5 years

Cardiac Function, Including Left Ventricular Ejection Fraction (LVEF) as Measured by Echocardiogram (ECHO)

measured Up to 5 years

Publications

PMID 41961051 — linked by the registry

Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.

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