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A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

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NCT06561685 · readout ≤ 438 d

Sponsored by Eli Lilly and Company (industry) · LLY — their whole pipeline →.

Phase
Phase 1
Status
Recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
340estimated
Sites
33
Countries
France, Germany, Japan +3

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2024-09-19actualWhen the study began enrolling
Primary completionOct 2027estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completionOct 2027estimatedThe whole study's end, after follow-up
First posted2024-08-20actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-08-07actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Conditions

  • Metastatic Solid Tumor
  • Advanced Solid Tumor
  • Non-small Cell Lung Cancer
  • SMARCA4-Deficient Tumor

Interventions

  • Drug: LY4050784
  • Drug: Pembrolizumab
  • Drug: Cisplatin
  • Drug: Carboplatin
  • Drug: Pemetrexed
  • Drug: Paclitaxel
  • Drug: Nab paclitaxel

Primary outcomes

what the primary-completion date above is the date OF
Phase Ia: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs), Serious Adverse Event(s) (SAEs), and Adverse Event(s) (AEs)
measured Up to Approximately 48 Months or 4 Years
Phase 1a: To determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D) of LY4050784
measured Up to Approximately 48 Months or 4 Years
Phase 1b: To assess the antitumor activity of LY4050784 Monotherapy: Overall response rate (ORR)
measured Up to Approximately 48 Months or 4 Years
Phase 1b (Dose optimization only): To confirm the RP2D/optimal dose based on safety and efficacy of LY4050784
measured Up to Approximately 48 Months or 4 Years
Phase 1b (Combination cohorts/Part C): To assess the safety and tolerability of LY4050784 when administered in combination with other anticancer agents
measured Up to Approximately 48 Months or 4 Years

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