Safety and Pharmacokinetics Study of MBX 2109 in Adult Subjects With Normal and Impaired Renal Function
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Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Na · None · Basic science
Enrollment
25actual
Sites
3
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-06-13 | actual | When the study began enrolling |
| Primary completion | 2025-09-04 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-09-04 | actual | The whole study's end, after follow-up |
| First posted | 2024-07-11 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-10-28 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Renal Impairment
Interventions
- Drug: MBX 2109
- Drug: MBX 2109
- Drug: MBX 2109
- Drug: MBX 2109
Primary outcomes
what the primary-completion date above is the date OFArea under the plasma concentration-time curve from time 0 extrapolated to infinity (AUC0-∞)
measured Baseline through Day 36
Maximum observed concentration (Cmax)
measured Baseline through Day 36
Area under the plasma concentration-time curve from time 0 to time of last quantifiable sample (AUC0-T)
measured Baseline through Day 36
Apparent clearance (CL/F) (MBX 2109 only)
measured Baseline through Day 36
Time to maximum concentration (Tmax)
measured Baseline through Day 36
Terminal elimination half-life (t1/2)
measured Baseline through Day 36
Apparent volume of distribution (Vz/F) (MBX 2109 only)
measured Baseline through Day 36
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