A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight
← catalyst calendarSponsored by Eli Lilly and Company (industry) · LLY — their whole pipeline →.
Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Randomized · None · Basic science
Enrollment
533actual
Sites
7
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-06-24 | actual | When the study began enrolling |
| Primary completion | 2025-06-02 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-06-02 | actual | The whole study's end, after follow-up |
| First posted | 2024-06-04 | actual | When this record first appeared on the registry |
| Results posted | 2026-07-17 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-07-17 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Healthy
- Obese
- Overweight
- Obesity
Intervention
- Drug: Orforglipron — also filed as LY3502970
Primary outcomes
what the primary-completion date above is the date OFPart B: Pharmacokinetics (PK): Steady-state Area Under the Concentration Time Curve From Time Zero to the End of the Dosing Interval, Tau (AUC[0-tau]) of LY3502970 on Day 7
measured Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days)
Part B: PK: Steady-state Maximum Observed Concentration (Cmax) of LY3502970 on Day 7
measured Pre-dose, 0.5, 1, 2, 4, 6, 8, 12, 16 and 24 hours post-dose on Day 7 for each dosing treatment period (1 period=7 days)
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-08-14 · 8.2 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-03-10 · 1.0 MB · SAP_001.pdf
Publications
- PMID 41994902 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
Permalink · LLY's whole pipeline · Catalyst calendar · Every registered study · What changed