An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting
← catalyst calendarNCT06398080 · readout in 502 d
Sponsored by Regeneron Pharmaceuticals (industry) · REGN — their whole pipeline →.
Phase
—
Status
Withdrawn
Study type
Observational
Enrollment
0actual
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
Sponsor Decision
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-12-12 | estimated | When the study began enrolling |
| Primary completion | 2028-01-03 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2029-01-03 | estimated | The whole study's end, after follow-up |
| First posted | 2024-05-03 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2024-11-25 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Neovascular Age-related Macular Degeneration (nAMD)
- Wet Age-related Macular Degeneration (AMD)
- Diabetic Macular Edema (DME)
- Visual Impairment
Intervention
- Drug: aflibercept 8 mg — also filed as EYLEA® HD
Primary outcomes
what the primary-completion date above is the date OFMean prior treatment interval during the one-year period before study enrollment compared to the last assigned treatment interval during the study
measured Up to 12 Months
Change in visual acuity (VA) (Early Treatment Diabetic Retinopathy study [ETDRS]) letters)
measured Baseline up to 12 Months
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