Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
← catalyst calendarNCT06333951 · readout in 72 d
Sponsored by Amgen (industry) · AMGN — their whole pipeline →.
Phase
Phase 1
Status
Active, not recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
49actual
Sites
83
Countries
Argentina, Australia, Austria +17
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-09-17 | actual | When the study began enrolling |
| Primary completion | 2026-10-31 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-11-30 | estimated | The whole study's end, after follow-up |
| First posted | 2024-03-27 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-05-28 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Thoracic Tumors
- Non-small Cell Lung Cancer
Interventions
- Drug: Anvumetostat — also filed as AMG 193
- Drug: Carboplatin
- Drug: Paclitaxel
- Drug: Pembrolizumab
- Drug: Pemetrexed
- Drug: Sotorasib
Primary outcomes
what the primary-completion date above is the date OFNumber of Participants Experiencing Dose Limiting Toxicities (DLT)
measured Up to approximately 21 days
Number of Participants Experiencing Treatment Emergent Adverse Events (TEAE)
measured Up to approximately 3 years
Number of Participants Experiencing Serious Adverse Events (SAE)
measured Up to approximately 3 years
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