Study Evaluating SC291 in Subjects With Severe r/r B-cell Mediated Autoimmune Diseases (GLEAM)
← catalyst calendarNCT06294236 · readout ≤ 499 d
Sponsored by Sana Biotechnology (industry) · SANA — their whole pipeline →.
Phase
Phase 1
Status
Active, not recruiting
Study type
Interventional
Design
Non randomized · None · Treatment
Enrollment
7estimated
Sites
5
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-04-29 | actual | When the study began enrolling |
| Primary completion | Dec 2027 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | Mar 2028 | estimated | The whole study's end, after follow-up |
| First posted | 2024-03-05 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-11-25 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Lupus Erythematosus
- Systemic Lupus Erythematosus
- SLE (Systemic Lupus)
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- Granulomatous Polyangiitis
- Microscopic Polyangiitis
Intervention
- Biological: SC291 — also filed as Cyclophosphamide, Fludarabine
Primary outcome
what the primary-completion date above is the date OFEvaluate safety and tolerability of SC291
measured 24 months
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