A Safety Study of PF-08046044/SGN-35C in Adults With Advanced Cancers
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Phase
Phase 1
Status
Terminated
Study type
Interventional
Design
Na · None · Treatment
Enrollment
58actual
Sites
33
Countries
Denmark, France, Italy +3
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The trial was terminated for strategic reasons due to portfolio reprioritization. The decision was not based on any safety or regulatory concerns
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-05-28 | actual | When the study began enrolling |
| Primary completion | 2026-04-13 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-04-13 | actual | The whole study's end, after follow-up |
| First posted | 2024-02-12 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-06 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Hodgkin Disease
- Lymphoma, T-Cell, Peripheral
- Lymphoma, Large B-Cell, Diffuse
- Lymphoma, Large-Cell, Anaplastic
Intervention
- Drug: PF-08046044/SGN-35C
Primary outcomes
what the primary-completion date above is the date OFNumber of participants with adverse events (AEs)
measured Through 30-37 days after last study treatment, approximately 1 year
Number of participants with laboratory abnormalities
measured Through 30-37 days after last study treatment, approximately 1 year
Number of participants with dose modifications due to AEs
measured Up to approximately 1 year
Number of participants with dose-limiting toxicities (DLTs)
measured Up to 21 days
Number of participants with DLTs by dose level
measured Up to 21 days
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