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A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

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NCT06221969

Sponsored by Novo Nordisk A/S (industry) · NVO — their whole pipeline →.

Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
1,024actual
Sites
196
Countries
Argentina, Australia, Canada +5

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2024-01-16actualWhen the study began enrolling
Primary completion2026-03-04actualThe date the last participant is measured for the primary outcome — the readout window
Study completion2026-04-06actualThe whole study's end, after follow-up
First posted2024-01-24actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-04-22actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Type 2 Diabetes

Interventions

  • Drug: Cagrilintide
  • Drug: Semaglutide
  • Drug: Tirzepatide

Primary outcomes

what the primary-completion date above is the date OF
Change in glycated haemoglobin (HbA1c)
measured From baseline (week 0) to end of treatment (week 68)
Relative change in body weight
measured From baseline (week 0) to end of treatment (week 68)

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