Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab
← catalyst calendarNCT06211036 · readout in 320 d
Sponsored by Amgen (industry) · AMGN — their whole pipeline →.
Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
563actual
Sites
219
Countries
Argentina, Australia, Austria +26
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2024-06-05 | actual | When the study began enrolling |
| Primary completion | 2027-07-05 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-09-30 | estimated | The whole study's end, after follow-up |
| First posted | 2024-01-18 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-12-17 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Extensive-Stage Small-Cell Lung Cancer
- Small-Cell Lung Cancer
Interventions
- Drug: Tarlatamab — also filed as AMG 757
- Drug: Durvalumab
Primary outcome
what the primary-completion date above is the date OFOS
measured Up to approximately 3 years
Publications
- PMID 40934933 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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