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Observational Study to Evaluate the Effect and Safety of Selumetinib in Pediatric Patients With NF1-PNs

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NCT06175637 · readout in 284 d

Sponsored by AstraZeneca (industry) · AZN — their whole pipeline →.

Phase
Status
Active, not recruiting
Study type
Observational
Enrollment
409actual
Sites
25
Country
China

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2023-12-20actualWhen the study began enrolling
Primary completion2027-05-30estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completion2027-05-30estimatedThe whole study's end, after follow-up
First posted2023-12-19actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-08-13actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Neurofibroma, Plexiform

Primary outcomes

what the primary-completion date above is the date OF
NF1-PN patient demographics and disease characteristics at baseline and during selumetinib treatment
measured From baseline to 24 months after first dose of selumetinib
NF1-PN disease characteristics
measured From baseline to 24 months after first dose of selumetinib
Selumetinib treatment profile
measured From baseline to 24 months after first dose of selumetinib
Physician's qualitative assessment of disease status for clinically significant PN and overall disease status
measured From baseline to 24 months after first dose of selumetinib
NF1 disease status
measured From baseline to 24 months after first dose of selumetinib

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