Observational Study to Evaluate the Effect and Safety of Selumetinib in Pediatric Patients With NF1-PNs
← catalyst calendarNCT06175637 · readout in 284 d
Sponsored by AstraZeneca (industry) · AZN — their whole pipeline →.
Phase
—
Status
Active, not recruiting
Study type
Observational
Enrollment
409actual
Sites
25
Country
China
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-12-20 | actual | When the study began enrolling |
| Primary completion | 2027-05-30 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2027-05-30 | estimated | The whole study's end, after follow-up |
| First posted | 2023-12-19 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-13 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Neurofibroma, Plexiform
Primary outcomes
what the primary-completion date above is the date OFNF1-PN patient demographics and disease characteristics at baseline and during selumetinib treatment
measured From baseline to 24 months after first dose of selumetinib
NF1-PN disease characteristics
measured From baseline to 24 months after first dose of selumetinib
Selumetinib treatment profile
measured From baseline to 24 months after first dose of selumetinib
Physician's qualitative assessment of disease status for clinically significant PN and overall disease status
measured From baseline to 24 months after first dose of selumetinib
NF1 disease status
measured From baseline to 24 months after first dose of selumetinib
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