Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria
← catalyst calendarSponsored by Mineralys Therapeutics Inc. (industry) · MLYS — their whole pipeline →.
Phase
Phase 2
Status
Completed
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
60actual
Sites
44
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-12-14 | actual | When the study began enrolling |
| Primary completion | 2025-02-27 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-04-23 | actual | The whole study's end, after follow-up |
| First posted | 2023-11-29 | actual | When this record first appeared on the registry |
| Results posted | 2026-06-03 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-06-03 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Chronic Kidney Disease
Interventions
- Drug: Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD
- Drug: Placebo QD + SGLT2i QD, Washout, Lorundrostat 25mg+SGLT2i QD
Primary outcome
what the primary-completion date above is the date OFPlacebo-adjusted Change From Baseline in Automated Office Blood Pressure (AOBP) Systolic Blood Pressure (SBP) at Week 4
measured Baseline to Week 4
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-03-28 · 917 KB · Prot_000.pdf
Statistical Analysis Planposted 2025-05-29 · 2.1 MB · SAP_001.pdf
Publications
- PMID 41805697 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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