AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
← catalyst calendarNCT06137118 · readout in 540 d
Sponsored by AstraZeneca (industry) · AZN — their whole pipeline →.
Phase
Phase 1/2
Status
Recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
255estimated
Sites
82
Countries
Australia, Brazil, Canada +10
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-12-29 | actual | When the study began enrolling |
| Primary completion | 2028-02-11 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2028-09-15 | estimated | The whole study's end, after follow-up |
| First posted | 2023-11-18 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-19 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- B-cell Acute Lymphoblastic Leukemia (B-ALL)
Intervention
- Drug: Surovatamig — also filed as AZD0486
Primary outcomes
what the primary-completion date above is the date OFPart A: Frequency of DLTs
measured Up to 28 days
Parts A & B: Safety Evaluation of AZD0486
measured From signing of informed consent through data cutoff, up to 57 months
Parts B & C: Rate of CR within 3 cycles
measured Up to three cycles of 28 days each
Part D: CR/CRh within 3 cycles
measured Up to three cycles of 28 days each
Publications
- PMID 41671463 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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