A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
← catalyst calendarSponsored by Novo Nordisk A/S (industry) · NVO — their whole pipeline →.
Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
2,734actual
Sites
405
Countries
Argentina, Australia, Brazil +29
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-09-27 | actual | When the study began enrolling |
| Primary completion | 2025-11-19 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-01-06 | actual | The whole study's end, after follow-up |
| First posted | 2023-10-04 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-07-08 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Type 2 Diabetes Mellitus
Interventions
- Drug: Cagrilintide
- Drug: Semaglutide
- Drug: Placebo cagrilintide
- Drug: Placebo semaglutide
Primary outcome
what the primary-completion date above is the date OFCagriSema (dose 1) versus semaglutide (dose 1): Change in glycated haemoglobin (HbA1c)
measured From baseline (week 0) to end of treatment (week 68)
Publications
- PMID 42251859 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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