A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension
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Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
796actual
Sites
263
Countries
Argentina, Australia, Austria +26
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-11-22 | actual | When the study began enrolling |
| Primary completion | 2025-05-21 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-10-10 | actual | The whole study's end, after follow-up |
| First posted | 2023-09-13 | actual | When this record first appeared on the registry |
| Results posted | 2026-07-30 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-07-30 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Uncontrolled Hypertension
- Resistant Hypertension
Interventions
- Drug: Baxdrostat — also filed as CIN-107
- Drug: Placebo
Primary outcomes
what the primary-completion date above is the date OFChange From Baseline in Seated Systolic Blood Pressure for 2 mg Baxdrostat
measured At Week 12
Change From Baseline in Seated Systolic Blood Pressure for 1 mg Baxdrostat
measured At Week 12
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-04-10 · 1.5 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-06-04 · 1.3 MB · SAP_001.pdf
Publications
- PMID 40888730 — linked by the registry
- PMID 40850955 — linked by the registry
- PMID 39138914 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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