A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors
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Phase
Phase 1
Status
Terminated
Study type
Interventional
Design
Na · None · Treatment
Enrollment
68actual
Sites
24
Countries
United Kingdom, United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The trial was terminated for strategic reasons. The decision was not based on any safety concerns
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-11-14 | actual | When the study began enrolling |
| Primary completion | 2026-04-16 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-04-16 | actual | The whole study's end, after follow-up |
| First posted | 2023-08-09 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-05-05 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- Colorectal Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Squamous Cell Carcinoma of the Head and Neck
- Pancreatic Ductal Adenocarcinoma
Intervention
- Drug: PF-08046052 — also filed as SGN-EGFRd2
Primary outcomes
what the primary-completion date above is the date OFNumber of participants with adverse events (AEs)
measured Through 90 days after last study treatment, up to approximately 1 year
Number of participants with laboratory abnormalities
measured Through 30-37 days after last study treatment, up to approximately 1 year
Number of participants with dose limiting toxicities (DLTs)
measured Up to 35 days
Number of participants with DLTs by dose level
measured Up to 35 days
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