A Study to Investigate the Safety and Efficacy of KER-012 in Combination With Background Therapy in Adult Participants With Pulmonary Arterial Hypertension (PAH) (TROPOS Study).
← catalyst calendarSponsored by Keros Therapeutics, Inc. (industry) · KROS — their whole pipeline →.
Phase
Phase 2
Status
Terminated
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
113actual
Sites
55
Countries
Australia, Brazil, France +8
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The study was voluntarily terminated early, following a safety review and observation of pericardial effusions.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-10-17 | actual | When the study began enrolling |
| Primary completion | 2025-03-05 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-03-11 | actual | The whole study's end, after follow-up |
| First posted | 2023-08-04 | actual | When this record first appeared on the registry |
| Results posted | 2026-07-02 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-07-02 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Pulmonary Arterial Hypertension
Interventions
- Biological: Dose A KER-012
- Biological: Dose B KER-012
- Biological: Dose C KER-012
- Biological: Placebo for 24 Weeks followed by Dose B KER-012 for 72 weeks
Primary outcome
what the primary-completion date above is the date OFChange From Baseline in PVR (Pulmonary Vascular Resistance)
measured Baseline and Week 24
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-12-18 · 1020 KB · Prot_000.pdf
Statistical Analysis Planposted 2025-04-02 · 1.6 MB · SAP_001.pdf
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