A Study to Evaluate Efficacy, Safety, and Tolerability of Darigabat in Participants With Panic Disorder
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Phase
Phase 2
Status
Terminated
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
80actual
Sites
31
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
Sponsor terminated due to significant enrollment and study design challenges
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-07-31 | actual | When the study began enrolling |
| Primary completion | 2025-03-31 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-03-31 | actual | The whole study's end, after follow-up |
| First posted | 2023-07-12 | actual | When this record first appeared on the registry |
| Results posted | 2026-05-07 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-05-07 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Panic Disorder
Interventions
- Drug: Darigabat — also filed as CVL-865
- Drug: Placebo
Primary outcome
what the primary-completion date above is the date OFPercentage of Participants Free of Panic Attacks as Assessed by Participant Daily eDiary During the Last Two Weeks of the Maintenance Treatment Period
measured Week 13-14
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-01-24 · 14.5 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-04-23 · 2.8 MB · SAP_001.pdf
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