Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM
← catalyst calendarSponsored by Cytokinetics (industry) · CYTK — their whole pipeline →. With Sanofi.
Phase
Phase 3
Status
Completed
Study type
Interventional
Design
Randomized · Triple · Treatment
Enrollment
175actual
Sites
71
Countries
Brazil, Canada, China +10
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2023-06-20 | actual | When the study began enrolling |
| Primary completion | 2025-02-28 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-03-28 | actual | The whole study's end, after follow-up |
| First posted | 2023-03-14 | actual | When this record first appeared on the registry |
| Results posted | 2026-06-09 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-06-09 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Obstructive Hypertrophic Cardiomyopathy (oHCM)
Interventions
- Drug: Aficamten (CK-3773274) (5 mg, 10 mg, 15 mg and 20 mg)
- Drug: Placebo to match aficamten
- Drug: Metoprolol succinate (50 mg, 100 mg, 150 mg and 200 mg)
- Drug: Placebo to match metoprolol succinate
Primary outcome
what the primary-completion date above is the date OFChange in Peak Oxygen Uptake (pVO2) by Cardiopulmonary Exercise Testing (CPET)
measured Baseline to Week 24
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-03-14 · 2.7 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-03-20 · 881 KB · SAP_001.pdf
Publications
- PMID 42307914 — linked by the registry
- PMID 41493295 — linked by the registry
- PMID 41348072 — linked by the registry
- PMID 40932433 — linked by the registry
- PMID 40888697 — linked by the registry
- PMID 39909646 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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