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Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

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NCT05611931 · readout ≤ 12 d

Sponsored by Karyopharm Therapeutics Inc (industry) · KPTI — their whole pipeline →. With GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgian Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology and 8 more.

Phase
Phase 3
Status
Active, not recruiting
Study type
Interventional
Design
Randomized · Double · Treatment
Enrollment
257actual
Sites
204
Countries
Australia, Belgium, Canada +14

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2023-04-18actualWhen the study began enrolling
Primary completionAug 2026estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completionJan 2028estimatedThe whole study's end, after follow-up
First posted2022-11-10actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-05-29actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Condition

  • Endometrial Cancer

Interventions

  • Drug: Selinexor — also filed as KPT-330
  • Drug: Matching Placebo for selinexor

Primary outcome

what the primary-completion date above is the date OF
Investigator assessed Progression Free Survival (PFS) per RECIST v1.1
measured From randomization until disease progression (PD) or death, whichever occurs first (up to 34 months)

Publications

Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.

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