Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications
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Phase
Phase 4
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Prevention
Enrollment
962actual
Sites
111
Countries
Australia, Austria, Belgium +11
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-11-07 | actual | When the study began enrolling |
| Primary completion | 2025-03-31 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-07-08 | actual | The whole study's end, after follow-up |
| First posted | 2022-08-26 | actual | When this record first appeared on the registry |
| Results posted | 2026-05-22 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-05-22 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Migraine
Interventions
- Drug: Rimegepant
- Drug: Placebo
Primary outcome
what the primary-completion date above is the date OFMean Change From Observation Phase (OP) in the Number of Migraine Days Per Month Over the Entire DBT Phase (Weeks 1 to 12)
measured Observation phase (28 days prior to randomization), DBT phase (through Month 3 [Week 1 to 12])
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2024-09-04 · 818 KB · Prot_000.pdf
Statistical Analysis Planposted 2025-05-20 · 773 KB · SAP_001.pdf
Publications
- PMID 42047365 — linked by the registry
- PMID 41255098 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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