Zibotentan and Dapagliflozin Combination, EvAluated in Liver Cirrhosis (ZEAL Study)
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Phase
Phase 2
Status
Terminated
Study type
Interventional
Design
Randomized · Triple · Screening
Enrollment
205actual
Sites
50
Countries
Australia, Austria, Belgium +12
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Why the sponsor stopped it
The study was ended earlier than planned due to a sponsor decision.
As filed on the registry record, in the sponsor's own words.
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-10-31 | actual | When the study began enrolling |
| Primary completion | 2025-05-22 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-07-17 | actual | The whole study's end, after follow-up |
| First posted | 2022-08-25 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-08-15 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Liver Cirrhosis
Interventions
- Drug: Part A: Placebo (matching zibotentan capsule & matching dapagliflozin tablet)
- Drug: Part A: zibotentan (dose B) + dapagliflozin
- Drug: Part B: Placebo (matching zibotentan capsule & matching dapagliflozin tablet)
- Drug: Part B: placebo (matching zibotentan capsule) + dapagliflozin
- Drug: Part B: zibotentan (dose A) + dapagliflozin
- Drug: Part B: zibotentan (dose B) + dapagliflozin
- Drug: Part B: zibotentan (dose C) + dapagliflozin
Primary outcomes
what the primary-completion date above is the date OFPart A: Absolute change in HVPG from baseline to Week 6.
measured at Week 6
Part B: Absolute change in HVPG from baseline to Week 6.
measured at Week 6
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