A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
← catalyst calendarNCT05489705 · readout in 1,094 d
Sponsored by Bristol-Myers Squibb (industry) · BMY — their whole pipeline →.
Phase
—
Status
Recruiting
Study type
Observational
Enrollment
1,700estimated
Sites
101
Countries
Austria, Czechia, France +6
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-08-16 | actual | When the study began enrolling |
| Primary completion | 2029-08-17 | estimated | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2029-08-17 | estimated | The whole study's end, after follow-up |
| First posted | 2022-08-05 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-08-19 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Obstructive Hypertrophic Cardiomyopathy
Interventions
- Drug: Mavacamten
- Drug: Non-mavacamten symptomatic oHCM therapy
Primary outcomes
what the primary-completion date above is the date OFIncidence rate of new or worsening heart failure due to systolic dysfunction among participants with symptomatic obstructive HCM during periods of exposure to mavacamten and other oHCM treatment
measured Up to 5 Years
Change in resting left ventricular outflow tract (LVOT) gradient from baseline
measured Up to 18 months
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