A Study to Learn About the Vepdegestrant (ARV-471, PF-07850327) in People With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (BC)
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Phase
Phase 1
Status
Active, not recruiting
Study type
Interventional
Design
Na · None · Treatment
Enrollment
6actual
Sites
3
Country
Japan
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-08-16 | actual | When the study began enrolling |
| Primary completion | 2023-05-04 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-03-31 | estimated | The whole study's end, after follow-up |
| First posted | 2022-07-19 | actual | When this record first appeared on the registry |
| Results posted | 2024-09-23 | actual | When the sponsor posted results to the registry |
| Record updated | 2024-11-13 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Breast Neoplasms
Intervention
- Drug: vepdegestrant — also filed as ARV-471, PF-07850327
Primary outcome
what the primary-completion date above is the date OFNumber of Participants With Dose Limiting Toxicity (DLTs) During First Treatment Cycle
measured Cycle 1 (28 days)
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2022-10-21 · 1.8 MB · Prot_000.pdf
Statistical Analysis Planposted 2023-05-25 · 504 KB · SAP_001.pdf
Publications
- PMID 39565495 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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