Observational Study in Multiple System Atrophy
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Phase
—
Status
Active, not recruiting
Study type
Observational
Enrollment
90estimated
Sites
8
Country
China
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-06-25 | actual | When the study began enrolling |
| Primary completion | 2024-03-12 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2031-05-30 | estimated | The whole study's end, after follow-up |
| First posted | 2022-07-12 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2025-12-08 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Multiple System Atrophy
Intervention
- Diagnostic test: plasma NfL and brain MRI (vMRI, DTI, and ASL [if feasible]) only for the EU cohort
Primary outcomes
what the primary-completion date above is the date OFTo describe early MSA disease progression changes in 6-month intervals over 12-months (i.e., baseline, 6-months, 12-months)
measured baseline, 6 months, 12 months
Changes from baseline to approx. 6-months after baseline and approx.12- months after baseline in plasma NfL concentrations.
measured baseline, 6 months, 12 months
Percentage change in brain volume in brain regions-of-interest (ROIs), as measured by volumetric MRI (vMRI).
measured baseline, 6 months, 12 months
Percentage change in tissue integrity in ROIs, as measured by diffusion-tensor imaging (DTI) MRI.
measured baseline, 6 months, 12 months
Publications
- PMID 42286509 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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