A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis
← catalyst calendarSponsored by Novo Nordisk A/S (industry) · NVO — their whole pipeline →.
Phase
Phase 2
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
105actual
Sites
39
Countries
Canada, Czechia, France +7
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-08-02 | actual | When the study began enrolling |
| Primary completion | 2025-02-17 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-05-13 | actual | The whole study's end, after follow-up |
| First posted | 2022-07-01 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-02-17 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Interventions
- Drug: NNC6019-0001
- Drug: Placebo (NNC6019-0001)
Primary outcomes
what the primary-completion date above is the date OFChange in 6-minute walk test (6-MWT)
measured From baseline (week 0) to visit 15 (week 52)
Change in N-terminal-pro brain natriuretic peptide (NT-proBNP)
measured From baseline (week 0) to visit 15 (week 52)
Publications
- PMID 41212997 — linked by the registry
- PMID 39472768 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
Permalink · NVO's whole pipeline · Catalyst calendar · Every registered study · What changed