A Study of Modified mRNA Vaccines in Healthy Adults
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Phase
Phase 1
Status
Completed
Study type
Interventional
Design
Randomized · None · Prevention
Enrollment
308actual
Sites
8
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-05-24 | actual | When the study began enrolling |
| Primary completion | 2026-02-27 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-02-27 | actual | The whole study's end, after follow-up |
| First posted | 2022-05-31 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-03-12 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Conditions
- SARS-CoV-2
- Seasonal Influenza
- Respiratory Syncytial Virus
- Cytomegalovirus
Interventions
- Biological: mRNA-1273
- Biological: mRNA-1010
- Biological: mRNA-1345
- Biological: FLUAD®
- Biological: mRNA-1647
Primary outcomes
what the primary-completion date above is the date OFNumber of Participants With Solicited Local and Systemic Reactogenicity Adverse Reactions (ARs)
measured Up to Day 176 (7 days follow-up post-vaccination)
Number of Participants With Unsolicited Adverse Events (AEs)
measured Up to Day 197 (28 days follow-up post-vaccination)
Number of Participants With Serious AEs (SAEs), AEs of Special Interest (AESIs), and AEs Leading to Study Withdrawal or Discontinuation of Study Vaccination
measured Day 1 through end of study (EOS) (up to Day 1249)
Number of Participants with Medically Attended Adverse Events (MAAEs)
measured Day 1 through Day 361
Publications
- PMID 41535296 — linked by the registry
- PMID 41398408 — linked by the registry
- PMID 40276503 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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