A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80
← catalyst calendarSponsored by Biogen (industry) · BIIB — their whole pipeline →. With Denali Therapeutics Inc..
Phase
Phase 2
Status
Completed
Study type
Interventional
Design
Randomized · Quadruple · Treatment
Enrollment
650actual
Sites
113
Countries
Austria, Canada, China +10
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-04-19 | actual | When the study began enrolling |
| Primary completion | 2026-03-09 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2026-03-09 | actual | The whole study's end, after follow-up |
| First posted | 2022-04-27 | actual | When this record first appeared on the registry |
| Results posted | — | When the sponsor posted results to the registry | |
| Record updated | 2026-06-04 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Parkinson Disease
Interventions
- Drug: BIIB122 — also filed as DNL151
- Drug: BIIB122-Matching Placebo
Primary outcome
what the primary-completion date above is the date OFTime to Confirmed Worsening in Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts II and III Combined Score Over the Treatment Period
measured Up to Week 144
Publications
- PMID 40680102 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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