Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States
← catalyst calendarSponsored by AstraZeneca (industry) · AZN — their whole pipeline →. With Parexel.
Phase
Phase 4
Status
Completed
Study type
Interventional
Design
Na · None · Treatment
Enrollment
286actual
Sites
37
Country
United States
Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →
Source: ClinicalTrials.gov, retrieved 2026-08-19
Dates
each axis at the precision it was filed, with the registry's own basis| Date | Filed | Basis | What it is |
|---|---|---|---|
| Start | 2022-04-29 | actual | When the study began enrolling |
| Primary completion | 2025-10-01 | actual | The date the last participant is measured for the primary outcome — the readout window |
| Study completion | 2025-10-01 | actual | The whole study's end, after follow-up |
| First posted | 2022-04-14 | actual | When this record first appeared on the registry |
| Results posted | 2026-07-16 | actual | When the sponsor posted results to the registry |
| Record updated | 2026-07-16 | actual | The sponsor's own last edit to this record — every projection above is as current as this date |
What it studies
Condition
- Asthma
Intervention
- Drug: Tezepelumab — also filed as AMG 157 or MEDI9929
Primary outcome
what the primary-completion date above is the date OFAnnualized Asthma Exacerbation Rate (AAER)
measured Baseline period (Week -52 to Week 0), Study period (Week 0 to Week 52)
Posted documents
hosted by the registry — we link, never re-serveStudy Protocolposted 2023-01-12 · 5.5 MB · Prot_000.pdf
Statistical Analysis Planposted 2025-06-11 · 1.9 MB · SAP_001.pdf
Publications
- PMID 42148905 — linked by the registry
- PMID 40388086 — linked by the registry
Linked on the registry record. A “linked by the registry” entry is NLM's own automated PubMed match, not a claim by the sponsor that the paper reports this study.
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