Skip to content
KStart free
AI InfrastructureDefenseQuantumAll studies →

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

← catalyst calendar

NCT05320198 · readout ≤ 284 d

Sponsored by Disc Medicine, Inc (industry) · IRON — their whole pipeline →.

Phase
Phase 1/2
Status
Recruiting
Study type
Interventional
Design
Randomized · None · Treatment
Enrollment
150estimated
Sites
30
Countries
Australia, United States

Every value on this page is a field the sponsor filed with ClinicalTrials.gov, reproduced. Dates are their own estimates, revised as a study runs, unless the registry marks them actual. sources →

Source: ClinicalTrials.gov, retrieved 2026-08-19

Dates

each axis at the precision it was filed, with the registry's own basis
DateFiledBasisWhat it is
Start2022-06-06actualWhen the study began enrolling
Primary completionMay 2027estimatedThe date the last participant is measured for the primary outcome — the readout window
Study completionJun 2027estimatedThe whole study's end, after follow-up
First posted2022-04-11actualWhen this record first appeared on the registry
Results postedWhen the sponsor posted results to the registry
Record updated2026-08-12actualThe sponsor's own last edit to this record — every projection above is as current as this date

What it studies

Conditions

  • Myelofibrosis; Anemia
  • Anemia
  • Myelofibrosis
  • Myelofibrosis Due to and Following Polycythemia Vera
  • Primary Myelofibrosis
  • Post-essential Thrombocythemia Myelofibrosis
  • Myelodysplastic Syndromes

Intervention

  • Drug: DISC-0974

Primary outcomes

what the primary-completion date above is the date OF
Safety and Tolerability of DISC-0974 (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Safety and Tolerability of DISC-0974 (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Safety and Tolerability of DISC-0974 (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Safety and Tolerability of DISC-0974 (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Safety and Tolerability of DISC-0974 assessed through blood testing (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Safety and Tolerability of DISC-0974 assessed through urine testing (Phase 1b only)
measured From Day 1 to the end of treatment on Day 169
Transfusion-dependent (TD) high cohort: transfusion independence (Phase 2 only)
measured From Day 1 to the end of treatment on Day 169
TD low cohort: transfusion independence (Phase 2 only)
measured From Day 1 to the end of treatment on Day 169
Non-transfusion-dependent (nTD) cohort: anemia response (Phase 2 only)
measured From Day 1 to the end of treatment on Day 169

Permalink · IRON's whole pipeline · Catalyst calendar · Every registered study · What changed